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Test de Vogel - AMS Labo

AMS Labo

BIOSEB

Test de Vogel

UGS LE865 Catégorie

Test de conflit devenu un standard pour le dépistage rapide
des propriétés anxiolytiques potentielles des médicaments

UGS LE865 Catégorie

De nombreux modèles animaux ont été mis au point pour tester les effets de traitements anti-anxiolytiques sur le comportement. L’action comportementale la plus fréquente est la capacité ‘des-anxiolytique’ à augmenter le taux de réponse supprimé par une punition ‘réponse dépendante’.

L’une des versions les plus populaires de cette technique à été mise au point par R.A.VOGEL en 1971 (Psychopharm. (Berl.), 21:1-7). Dans ce modèle, la suppression de la prise de boisson au biberon chez des rats privés d’eau est rétablie par un prétraitement anxiolytique. Ce test peut être utilisé sur des rats naïfs en une seule session. Ce test est devenu un standard pour le screening rapide des effets anxiolytiques de nouveau traitements.

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